Research pointers: Platelet responsiveness to aspirin in patients with hyperlipidaemia

doi:10.1136/bmj.326.7380.82

BMJ 2003;326:82-83 ( 11 January )

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Research pointers

Platelet responsiveness to aspirin in patients with hyperlipidaemia

Platelet responsiveness to aspirin is reduced in patients with hyperlipidaemia

Maribeth Friend, graduate student ^a, Ivana Vucenik, associate professor ^a, Michael Miller, associate professor of medicine and epidemiology ^b.

^a Department of Medical and Research Technology and Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA, ^b Division of Cardiology, University of Maryland Medical Center

Correspondence to: M Miller mmiller@heart.umaryland.edu

The first 150 words of the full text of this article appear below.

Aspirin 325 mg/day reduces the rate of events associated with coronary heart disease. In most people, aspirin produces irreversibleinhibition of platelet aggregation, but in a sizeable minorityof patients, the degree of platelet aggregation needed to preventevents according to in vitro assessments is not achieved.¹Risk factors for coronary heart disease may contribute to aspirinresistance (the inability of aspirin to protect individuals fromthrombotic complications), so aspirin may not be cardioprotectivein patients with hyperlipidaemia.² We evaluated patients witha range of cholesterol concentrations to determine the impactof hypercholesterolaemia on platelet responsiveness in patientstreated withaspirin.

Participants, methods, and results

Consecutive patients (n=56) were recruited from the University of Maryland Preventive Cardiology Outpatient Center. The mean(SD) age was 54.3 (11.1) years, and 40 (72%) of the patients weremen. Patients were eligible if they were taking aspirin 325 mg/dayand presented with a history of coronary heart disease or at leasttwo . . . [Full text of this article]

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Rapid Responses:

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